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Adsense is a great publisher program especially for those who are not familiar with affiliate programs. As real people know how to avoid those ads we - the publishers - have to constantly optimize our advertisements in order to have better earnings.

Bellow are some tips that will help you achieve that :

1. Use custom channels for each section of your site. This will help you know which sections are better, and which need improvements
2. Put the ads somewhere that visitors can see them. The best is to have one 728×90 ad after your site’s header, and a big box (336×280) after the content. This way you give “options” to the visitors that finish reading your articles
3. Take a look at the official adsense heat map. If your site is a forum you may want to check this one.
4. Use blue color for your links (#0000FF) For some reason people click more on ads with this color. If your site is a forum make sure that the colors are rotating.
5. If the ads in your site are not relevant to your content use section targeting.
6. Participate in webmaster forums. You can find many useful information and professionals to help you out.
7. Don’t be afraid to make changes. Trial and error is the only way to success in this business, so after you follow the tip #1 be sure to make frequently changes until you find which are the best placements for your site.

Hope those tips help. If you have to add something please comment on this post or drop me a line